Cryptococcal meningitis is one of the most common opportunistic infections among HIV/AIDS patients, estimating more than 220,000 cases and 181,000 deaths worldwide each year. Early detection and treatment of infection are key to reducing the mortality associated with this disease.
The CrAg LFA is highly sensitive and specific, with a rapid turnaround time of just 10 minutes.
SERUM | Positive % Agreement | Negative % Agreement |
---|---|---|
CrAg EIA | 100% | 93% |
SERUM | Positive % Agreement | Negative % Agreement | Total % Agreement |
---|---|---|---|
Meridian LA | 100% | 100% | 99.8% |
When tested against Meridian’s EIA, the CrAg LFA showed high diagnostic performance in 197 serum specimens. The Crag LFA agreed with 100% of the Meridian EIA positive test results, and 93% of the Meridian EIA negative test results.
Culture/India Ink | SERUM1,2 | CSF1,2 | PLASMA2 | WHOLE BLOOD2 |
---|---|---|---|---|
Sensitivity | 100% | 100% | 98.9% | 99.3% |
Specificity | 100% | 100% | 100% | 94.4% |
When tested against culture and India ink, the CrAg LFA showed high diagnostic performance in all specimen types.
From the table above, we can conclude that the CrAg LFA will correctly generate a positive result for 100% of patients with Cryptococcus in serum and CSF samples, and 98% in Plasma and Whole Blood samples.
The CrAg LFA will correctly generate a negative result for 100% of patients without Cryptococcus in serum, CSF, and Plasma samples, and 94% in Whole Blood samples.
Cryptococcus Antigen LFA | 50 tests | CR2003 |
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