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TIME

Cryptococcal meningitis is one of the most common opportunistic infections among HIV/AIDS patients, estimating more than 220,000 cases and 181,000 deaths worldwide each year. Early detection and treatment of infection are key to reducing the mortality associated with this disease.

The CrAg LFA is highly sensitive and specific, with a rapid turnaround time of just 10 minutes.

Whole Blood, Serum, Plasma & CSF
FDA: Serum, CSF

SERUM	Positive % Agreement	Negative % Agreement
CrAg EIA	100%	93%

SERUM

Positive % Agreement

Negative % Agreement

CrAg EIA

100%

93%

SERUM	Positive % Agreement	Negative % Agreement	Total % Agreement
Meridian LA	100%	100%	99.8%

SERUM

Positive % Agreement

Negative % Agreement

Total % Agreement

Meridian LA

100%

99.8%

Culture/India Ink	SERUM	CSF	PLASMA	WHOLE BLOOD
Sensitivity	100%	100%	98.9%	99.3%
Specificity	100%	100%	100%	94.4%

Culture/India Ink

SERUM

CSF

PLASMA

WHOLE BLOOD

Sensitivity

100%

98.9%

99.3%

Specificity

100%

94.4%


Cryptococcal Meningitis Diagnostics and Screening in the Era of Point-of-Care Laboratory Testing Rajasingham R, Wake RM, Beyene T, Katende A, Letang E, Boulware DR. Cryptococcal Meningitis Diagnostics and Screening in the Era of Point-of-Care Laboratory Testing. J Clin Microbiol. 2019 Jan 2;57(1).
Point-of-Care Diagnosis and Prognostication of Cryptococcal Meningitis With the Cryptococcal Antigen Lateral Flow Assay on Cerebrospinal Fluid Kabanda T, Siedner MJ, Klausner JD, Muzoora C, Boulware DR. Point-of-care diagnosis and prognostication of cryptococcal meningitis with the cryptococcal antigen lateral flow assay on cerebrospinal fluid. Clin Infect Dis. 2014;58(1):113–116.
Large-scale clinical validation of a lateral flow immunoassay for detection of cryptococcal antigen in serum and cerebrospinal fluid specimens Suwantarat N, Dalton JB, Lee R, Green R, Memon W, Carroll KC, Riedel S, Zhang SX. Large-scale clinical validation of a lateral flow immunoassay for detection of cryptococcal antigen in serum and cerebrospinal fluid specimens. Diagn Microbiol Infect Dis. 2015 May;82(1):54-6.
CrAg lateral flow assay for cryptococcosis. Kozel TR, Bauman SK. CrAg lateral flow assay for cryptococcosis. Expert Opin Med Diagn. 2012;6(3):245–251.
5) Performance of the Cryptococcal Antigen Lateral Flow Assay in Non-HIV-Related Cryptococcosis Jitmuang A, Panackal AA, Williamson PR, Bennett JE, Dekker JP, Zelazny AM. Performance of the Cryptococcal Antigen Lateral Flow Assay in Non-HIV-Related Cryptococcosis. J Clin Microbiol. 2016;54(2):460–463.

Cryptococcal Meningitis Diagnostics and Screening in the Era of Point-of-Care Laboratory Testing
Rajasingham R, Wake RM, Beyene T, Katende A, Letang E, Boulware DR. Cryptococcal Meningitis Diagnostics and Screening in the Era of Point-of-Care Laboratory Testing. J Clin Microbiol. 2019 Jan 2;57(1).

Point-of-Care Diagnosis and Prognostication of Cryptococcal Meningitis With the Cryptococcal Antigen Lateral Flow Assay on Cerebrospinal Fluid
Kabanda T, Siedner MJ, Klausner JD, Muzoora C, Boulware DR. Point-of-care diagnosis and prognostication of cryptococcal meningitis with the cryptococcal antigen lateral flow assay on cerebrospinal fluid. Clin Infect Dis. 2014;58(1):113–116.

Large-scale clinical validation of a lateral flow immunoassay for detection of cryptococcal antigen in serum and cerebrospinal fluid specimens
Suwantarat N, Dalton JB, Lee R, Green R, Memon W, Carroll KC, Riedel S, Zhang SX. Large-scale clinical validation of a lateral flow immunoassay for detection of cryptococcal antigen in serum and cerebrospinal fluid specimens. Diagn Microbiol Infect Dis. 2015 May;82(1):54-6.

CrAg lateral flow assay for cryptococcosis.
Kozel TR, Bauman SK. CrAg lateral flow assay for cryptococcosis. Expert Opin Med Diagn. 2012;6(3):245–251.

5) Performance of the Cryptococcal Antigen Lateral Flow Assay in Non-HIV-Related Cryptococcosis
Jitmuang A, Panackal AA, Williamson PR, Bennett JE, Dekker JP, Zelazny AM. Performance of the Cryptococcal Antigen Lateral Flow Assay in Non-HIV-Related Cryptococcosis. J Clin Microbiol. 2016;54(2):460–463.