CrAg®

LFA

CRYPTOCOCCAL ANTIGEN


It's About

TIME

Cryptococcal meningitis is one of the most common opportunistic infections among HIV/AIDS patients, estimating more than 220,000 cases and 181,000 deaths worldwide each year. Early detection and treatment of infection are key to reducing the mortality associated with this disease.

The CrAg LFA is highly sensitive and specific, with a rapid turnaround time of just 10 minutes.

Whole Blood, Serum, Plasma & CSF
FDA: Serum, CSF
Results in just

10 MINUTES

Accuracy
Highly

SENSITIVE & SPECIFIC

No

PRETREATMENT REQUIRED


Clinical Relevancy

SERUM Positive % Agreement Negative % Agreement
CrAg EIA 100% 93%
1.IMMY CrAg Package Insert
SERUM Positive % Agreement Negative % Agreement Total % Agreement
Meridian LA 100% 100% 99.8%
2. Binnicker MJ, et al. Comparison of Four Assays for the Detection of Cryptococcal Antigen. Clin and Vacc Immuno. 2012; 19(18):1988.
Culture/India Ink SERUM CSF PLASMA WHOLE BLOOD
Sensitivity 100% 100% 98.9% 99.3%
Specificity 100% 100% 100% 94.4%
1.IMMY CrAg Package Insert

Cryptococcal Meningitis Diagnostics and Screening in the Era of Point-of-Care Laboratory Testing
Rajasingham R, Wake RM, Beyene T, Katende A, Letang E, Boulware DR. Cryptococcal Meningitis Diagnostics and Screening in the Era of Point-of-Care Laboratory Testing. J Clin Microbiol. 2019 Jan 2;57(1).
Point-of-Care Diagnosis and Prognostication of Cryptococcal Meningitis With the Cryptococcal Antigen Lateral Flow Assay on Cerebrospinal Fluid
Kabanda T, Siedner MJ, Klausner JD, Muzoora C, Boulware DR. Point-of-care diagnosis and prognostication of cryptococcal meningitis with the cryptococcal antigen lateral flow assay on cerebrospinal fluid. Clin Infect Dis. 2014;58(1):113–116.
Large-scale clinical validation of a lateral flow immunoassay for detection of cryptococcal antigen in serum and cerebrospinal fluid specimens
Suwantarat N, Dalton JB, Lee R, Green R, Memon W, Carroll KC, Riedel S, Zhang SX. Large-scale clinical validation of a lateral flow immunoassay for detection of cryptococcal antigen in serum and cerebrospinal fluid specimens. Diagn Microbiol Infect Dis. 2015 May;82(1):54-6.
CrAg lateral flow assay for cryptococcosis.
Kozel TR, Bauman SK. CrAg lateral flow assay for cryptococcosis. Expert Opin Med Diagn. 2012;6(3):245–251.
5) Performance of the Cryptococcal Antigen Lateral Flow Assay in Non-HIV-Related Cryptococcosis
Jitmuang A, Panackal AA, Williamson PR, Bennett JE, Dekker JP, Zelazny AM. Performance of the Cryptococcal Antigen Lateral Flow Assay in Non-HIV-Related Cryptococcosis. J Clin Microbiol. 2016;54(2):460–463.
Cryptococcus Antigen LFA 50 tests CR2003